ABSTRACT
Background: To compare the cord blood lipid profile of 100 newborn babies born to hypertensive (Group A) and normotensive mothers (Group B).Methods: Total 100 newborns were taken, 50 born to hypertensive mothers and 50 to normotensive mothers. 5ml umbilical venous blood was collected, after clamping the cord, from placental side of the cord and sent to laboratory for centrifugation. Serum was analysed for lipid profile by spectrophotometry by siemens dimensional Rxl- Total Cholesterol, Triglycerides, High density lipoprotein and Low density lipoprotein and Very low density lipoprotein. Comparison of the cord blood lipid levels in both the groups was done.Results: Cord blood lipid profile was deranged in newborns of hypertensive mothers with Cord TC, TG and LDL being statistically significantly higher than the mean reference value and 95th centile. Cord blood of term newborns of hypertensive mothers had Cord TC TG and LDL being statistically higher whereas only Cord TC being statistically higher in preterm neonates of hypertensive mothers.Conclusions: Cord blood lipid levels were significantly deranged in newborns of hypertensive mothers. This helps us in providing the target population at risk and cord blood lipid profile of newborn serving as an indirect guide for lifestyle modifications and helping in early intervention and prevention of future coronary heart disease.
ABSTRACT
Background: To compare the determinants of neonatal morbidity in late preterms and terms.Methods: A total of 100 live late preterm (34-0/7 to 36-6/7 weeks) and 100 term infants (37-0/7 to 41-6/7 weeks) admitted in sri guru ram das institute of medical sciences and research were randomly selected to participate in this case control study. The study group include 100 neonates within gestation age of 34 0/7 to 36 6/7 weeks. Equal number of terms between 37 0/7 to 41-6/7 gestation age was taken for comparison. The maternal history including both antenatal and natal history as well as new-born profile was taken.Results: Maternal risk factors have been found to be the major determinants of morbidity in late preterms with PROM (p<0.0001), sepsis and hypertension being significant contributors. Respiratory distress, neonatal jaundice, sepsis has been found to be major morbidity factors in late preterms. The average duration of admission was higher in late preterms than terms.Conclusions: Late preterm infants have higher risks for acute metabolic complications, mortality and long-term disabilities as compared to term infants. Morbidities like respiratory distress, neonatal jaundice, sepsis, hypoglycaemia and hypothermia are more in late preterms due to their immaturity. The risks associated with late preterm birth suggest the need for refinement of obstetric paradigms to extend pregnancy duration if benefits outweigh risk to fetus and mother. There is need to make obstetricians and families aware of complications pertaining to late preterm birth and improving surveillance of high-risk pregnancies.
ABSTRACT
Background: The neonatal transport in India has taken a giant leap in last years. For reducing the death among transported newborns, transport in well-equipped ambulance could play a vital role. As there is not much data available in Punjab on neonates being transported to tertiary care center so the present study was conducted to know the predictors of mortality in newborns transported to tertiary care center.Methods: The present study was an observational study conducted in neonatal intensive care unit of department of Pediatrics at SGRD institute of medical science and research, Amritsar, Punjab, India over a period of 18 months from 1st January 2017 to 30th June 2018. Total 121 neonates were enrolled in the study. History and clinical examination were done at the time of admission and the various study variables were statistically analysed.Results: Out of total 121 neonates, 76 were discharged, 12 expired and 33 left against medical advice. Mortality rate was 9.9%. Mortality was higher in neonates who had hypothermia, hypoglycemia, poor perfusion and bradycardia at the time of admission. Neonates with extremely low birth weight (<1 kg) and those admitted after 6 hours of age also had higher mortality.Conclusions: Predictors of mortality were hypothermia, hypoglycaemia, poor perfusion and bradycardia at the time of admission. New-borns require special care for stabilization before and during transport, which can be achieved by using specially equipped neonatal ambulances. So, these neonatal ambulances should be started in all states to decrease the neonatal mortality rate.